Cholecalciferol 50 µg (IU2000)

Cholecalciferol (Vitamin D3) contributes signifi cantly to calciumphosphorous metabolism. Active form of Vitamin D3 enhances calcium absorption in intestinal tract, calcium integration with osteoid and calcium release for bone tissue. Defi ciency of Vitamin D3 results in rachitis and osteomalacia, causes secondary hyperparathyroidism that enhances metabolism in bone tissue and can provoke bone fragility and fracture. Vitamin D3 is a precursor of steroid hormones.

1) Prophylaxis of Vitamin D3 defi ciency in adults and children:
Standard recommended daily dose of Vitamin D3 IU500/1000.
Therapeutic dose and course duration is individual subject to initial severity of Vitamin D3 defi ciency proved by laboratory results, age, Vitamin D3 supply from other sources (like food, insolation), body overweight of a patient. Recommended daily dose of Vitamin D3 is IU5000/6000. Course of medical treatment is 6 to 8 weeks with further laboratory monitoring of 25-Hydroxicholecalcipherol blood level and the decision to continue intake or to change for a preventive dose.

2) Supplement to specifi c therapy of osteoporosis in patients with Vitamin D3 defi ciency or risk of defi ciency: Recommended dose is IU1000 daily or IU7000 weekly or alternative dose IU50000 monthly.
For elderly patients under risk of fall and fracture recommended dose of Vitamin D3 is IU2000 daily. Patient needs additional calcium in case of insuffi cient calcium diet.

3) Certain groups of population undergo high risk of Vitamin D3 defi ciency, and require higher doses and level monitoring of 25-hrdroxicholecalciferol in blood serum:
— patients suff ering alcoholism;
— hospital patients;
— dark-skinned persons;
— patients with hepatobiliary diseases like hepatic disorder, cirrhosis, obstructive jaundice;
— patients with malabsorption including intestine infl ammation diseases, persistent
diarrhea and celiac disease;
— patients with obesity;
— patients with diagnosed osteoporosis;
— patients taking concurrent drugs (for example, anticonvulsive, glucocorticoids);
— persons with defi ciency of sun exposure, including children.